PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 10193253

Persistent cough: is it asthma?

A O Faniran·J K Peat·A J Woolcock
View original source ↗Export metadata ↓

Abstract

The aim of this study was to determine if children in the community with persistent cough can be considered to have asthma. A validated questionnaire was given to the parents of 1245 randomly selected children aged 6-12 years. Atopy was measured with skin prick tests. Children with persistent cough had less morbidity and less atopy compared with children with wheeze. Although the syndrome commonly referred to as "cough variant asthma" could not be shown in this study, a significant number of children with persistent cough had been diagnosed as having asthma and were treated with asthma medications including inhaled corticosteroids. Studies are urgently needed to determine the appropriate treatment for children with persistent cough.

Explore related subjects

Anti-Asthmatic AgentsAsthmaChildChronic DiseaseCoughFemaleHumansHypersensitivity, ImmediateMaleRespiratory SoundsTobacco Smoke PollutionJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A O Faniran, J K Peat, A J Woolcock. 1998. Persistent cough: is it asthma?. https://doi.org/10.1136/adc.79.5.411

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2001

An alternative parameterization of the general linear mixture model for longitudinal data with non-ignorable drop-outs.

This paper considers the mixture model methodology for handling non-ignorable drop-outs in longitudinal studies with continuous outcomes. Recently, Hogan and Laird have developed a mixture model for non-ignorable drop-outs which is a standard linear mixed effects model except that the parameters which characterize change over time depend also upon time of drop-out. That is, the mean response is linear in time, other covariates and drop-out time, and their interactions. One of the key attractions of the mixture modelling approach to drop-outs is that it is relatively easy to explore the sensitivity of results to model specification. However, the main drawback of mixture models is that the parameters that are ordinarily of interest are not immediately available, but require marginalization of the distribution of outcome over drop-out times. Furthermore, although a linear model is assumed for the conditional mean of the outcome vector given time of drop out, after marginalization, the unconditional mean of the outcome vector is not, in general, linear in the regression parameters. As a result, it is not possible to parsimoniously describe the effects of covariates on the marginal distribution of the outcome in terms of regression coefficients. The need to explicitly average over the distribution of the drop-out times and the absence of regression coefficients that describe the effects of covariates on the outcome are two unappealing features of the mixture modelling approach. In this paper we describe a particular parameterization of the general linear mixture model that circumvents both of these problems.

Anti-Asthmatic Agents↗
PubMed2001

Management of asthma in children.

The prevalence of asthma in children has increased 160 percent since 1980, and the disease currently affects nearly 5 million children in the United States. The National Asthma Education and Prevention Program provides guidelines for improved asthma care. The goals of this program are to limit the frequency, severity and costliness of asthma exacerbations through extensive education of physicians, children and caregivers. The four components of asthma management include regular assessment and monitoring, control of factors that contribute to or aggravate symptoms, pharmacologic therapy and education of children and their caregivers. The guidelines recommend a stepwise approach to pharmacologic treatment, starting with aggressive therapy to achieve control and followed by a "step down" to the minimal therapy that will maintain control. Quick relief of symptoms can be achieved preferentially by the use of short-acting beta2 agonists. Medications for long-term control should be considered for use in children with persistent symptoms. Inhaled corticosteroids are the most potent long-term anti-inflammatory medications. Other options include long-acting beta2 agonists, cromolyn sodium and nedocromil, antileukotriene agents and theophylline. All have advantages and disadvantages in individual situations.

Anti-Asthmatic Agents↗
PubMed2001

Bayesian cost-effectiveness analysis from clinical trial data.

A key tool for assessing the relative cost-effectiveness of two treatments in health economics is the incremental C/E acceptability curve. We present Bayesian computations for this curve in the case where data on both costs and efficacy are available from a clinical trial. Analysis is given under various formulations of prior information. A case study is analysed in which reasonable prior information is shown to strengthen substantially the posterior inference, leading to a more conclusive assessment of cost-effectiveness. Calculations can be performed using readily available Bayesian software.

Anti-Asthmatic Agents↗