Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex.

C M Müller; C B Griesinger

doi:10.1038/248

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PubMed · 10195108

Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex.

C M Müller·C B Griesinger

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Abstract

Preventing visual input to one eye (monocular deprivation) in early postnatal development reduces cortical responses to stimulation of the deprived eye, with a significant loss of thalamocortical connections. These effects are reversible by opening the deprived eye and closing the previously open eye (reverse occlusion). We show that intracortical blockade of tissue plasminogen activator or plasmin selectively prevents recovery of cortical function and thalamic neuron size during reverse occlusion, without affecting the monocular deprivation response. Therefore, a proteolytic cascade consisting of plasmin generated by tissue plasminogen activator may selectively mediate reverse-occlusion-induced cortical plasticity, perhaps via structural remodeling of axons.

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Animals Animals, Newborn Cats Cell Size Fibrinolysin Geniculate Bodies Leupeptins Neuronal Plasticity Plasminogen Activators Sensory Deprivation Tissue Plasminogen Activator Vision, Monocular Visual Cortex Journal Article Research Support, Non-U.S. Gov't

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C M Müller, C B Griesinger. 1998. Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex.. https://doi.org/10.1038/248

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