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Experience with lung transplantation.

A Haverich
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Abstract

BACKGROUND: On the basis of a 5-year experience with heart transplantation and long-term animal experimentation, a lung transplantation program was instituted in 1987. After 10 years of experience, the entire patient population was reviewed. METHODS: Hospital records were reviewed to evaluate the underlying diagnosis, year of transplantation, type of procedure, and long-term follow-up. The changing scope of indications, procedures performed, and donor criteria, as well as survival data for various subgroups of high-risk candidates, were also examined. RESULTS: A total of 283 heart-lung (n = 46), single-lung (n = 94), and bilateral lung transplantation procedures (n = 143) were performed, with 22 patients undergoing 24 retransplantation procedures. The overall 5-year survival rate was 63%, with no difference between types of operations. Patients with cystic fibrosis, emphysema, pulmonary fibrosis, and secondary pulmonary hypertension showed similar survival rates; primary pulmonary hypertension was associated with a lower long-term survival. In all groups, the bronchiolitis obliterans syndrome occurred at a rate of approximately 15%/year. CONCLUSIONS: Acceptable long-term results can be obtained with lung transplantation. Because of expanded indications, no survival benefit was gained in the overall population over a 10-year period. The major obstacle to true long-term survival remains the bronchiolitis obliterans syndrome.

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AdultAgedAnimalsFemaleFollow-Up StudiesHumansLung DiseasesLung TransplantationMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesRisk AssessmentSurvival RateAddress

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BibTeXRIS

A Haverich. 1999. Experience with lung transplantation.. https://doi.org/10.1016/s0003-4975(99)00021-1

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