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PubMed · 10197905

Impaired allocentric spatial working memory and intact retrograde memory after thalamic damage caused by thiamine deficiency in rats.

D G Mumby·L Cameli·M J Glenn
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Abstract

Rats were tested on an allocentric-spatial working-memory task--delayed matching-to-place (DMTP) in a water maze--before and after either pyrithiamine-induced thiamine deficiency (PTD) or electrolytic lesions of the lateral internal medullary laminae (IML), an area damaged by PTD. DMTP trials consisted of paired swims, with the escape platform in a new location on each trial. PTD rats were impaired at retention delays of 300 s, but not at delays of 4 or 60 s. Rats with IML lesions performed normally at all delays. Both groups displayed normal retention of object-discrimination problems that they had learned at different intervals before treatment (5 weeks, 3 weeks, and 1 week). The results suggest that PTD causes delay-dependent deficits of allocentric spatial working memory and that damage outside the IML is probably responsible. Neither PTD-induced diencephalic damage nor restricted IML lesions appear to produce a global retrograde amnesia.

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AnimalsBrain Damage, ChronicBrain MappingEscape ReactionMaleMaze LearningMental RecallOrientationRatsRats, Long-EvansRetention, PsychologyThalamusThiamine DeficiencyJournal ArticleResearch Support, Non-U.S. Gov't

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D G Mumby, L Cameli, M J Glenn. 1999. Impaired allocentric spatial working memory and intact retrograde memory after thalamic damage caused by thiamine deficiency in rats.. https://pubmed.ncbi.nlm.nih.gov/10197905/

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