PubMed · 10201244
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Y Mizuno, M Mori, K Ohba, K Kumada, T Owaki, S Kamiya, H Kawai. 1999. [Amoebic liver abscess].. https://pubmed.ncbi.nlm.nih.gov/10201244/
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A poly(carmine) film-modified glassy carbon electrode (GCE) was fabricated and the electrochemical behavior of tinidazole at the modified electrode was investigated by electrochemical methods. A well-defined reduction peak was observed at 0.61 V and was applied for the determination of tinidazole. Compared with that at a bare GCE, the reduction peak potential of tinidazole shifted negatively and the reduction peak current increased significantly. The influences of some parameters on the reduction of tinidazole were also examined. Based on the experimental data, a possible mechanism was proposed for the electrochemical reaction of tinidazole at the modified electrode. It was found that the reduction peak current was proportional to the concentration of tinidazole in the range from 1.0 x 10(-7) to 5.0 x 10(-5)mol L(-1). The detection limit was about 1.0 x 10(-8)mol L(-1) after accumulation 90 s at a constant potential of 0.0 V. The proposed method was applied to determine tinidazole in drugs and the result was satisfied.
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A simple and rapid stability-indicating HPLC assay procedure has been developed and validated for metronidazole benzoate. The HPLC conditions were as follows, column: Waters Symmetry C8, 5 microm packing, 4.6 mm x 250 mm; detection: UV at 271 nm; injection volume: 20 microl; mobile phase: acetonitrile-0.1% glacial acetic acid in monobasic potassium phosphate (0.01 M) (40:60, v/v); isocratic elution under ambient temperature at 2.0 ml min(-1). The procedure separated metronidazole benzoate and its potential degradation products, metronidazole and benzoic acid, in an overall analysis time of about 6 min with metronidazole benzoate eluting at about 5 min. The injection repeatability was 0.03%, and the intraday and interday repeatability were 0.4 and 0.7%, respectively. The procedure provided a linear response over the concentration range 0.2-800 microg ml(-1) (r=1.0000) with the limits of detection and quantitation 0.03 and 0.2 microg ml(-1), respectively. The solubilities of metronidazole benzoate in water, 0.01 M hydrochloric acid and 0.05 M phosphate buffer, pH 6.8, determined each in triplicate using the procedure, were 0.2 mg ml(-1) (R.S.D. 7%), 0.4 mg ml(-1) (R.S.D. 2%) and 0.2 mg ml(-1) (R.S.D. 8%), respectively. The results show no detectable hydrolysis of metronidazole benzoate in 0.01 M hydrochloric acid at 37 degrees C or in the mobile phase at ambient temperature in 10 h.