Separating sister chromatids.

K Nasmyth

doi:10.1016/s0968-0004(99)01358-4

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PubMed · 10203756

Separating sister chromatids.

K Nasmyth

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Abstract

Loss of cohesion between sister chromatids triggers their segregation during anaphase. Recent work has identified both a cohesin complex that holds sisters together and a sister-separating protein, separin, that destroys cohesion. Separins are bound by inhibitory proteins whose proteolysis at the metaphase-anaphase transition is mediated by the anaphase-promoting complex and its activator protein CDC20 (APCCDC20). When chromosomes are misaligned, a surveillance mechanism (checkpoint) blocks sister separation by inhibiting APCCDC20. Defects in this apparatus are implicated in causing aneuploidy in human cells.

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Anaphase Anaphase-Promoting Complex-Cyclosome Animals Cell Cycle Proteins Chromatids Humans Ligases Meiosis Metaphase Ubiquitin-Protein Ligase Complexes Ubiquitin-Protein Ligases Journal Article Review

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K Nasmyth. 1999. Separating sister chromatids.. https://doi.org/10.1016/s0968-0004(99)01358-4

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