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PubMed · 10209157

Multiple signals converging on NF-kappaB.

F Mercurio·A M Manning
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Abstract

The recent identification of molecular components of the signal transduction pathway regulating activation of nuclear factor-kappaB (NF-kappaB) in response to cytokines such as tumor necrosis factor alpha and interleukin-1beta allows the evaluation of how other diverse stimuli impinge on the NF-kappaB activation pathway. These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote.

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Amino Acid SequenceAnimalsCalcium-Calmodulin-Dependent Protein KinasesDNA-Binding ProteinsEmbryonic and Fetal DevelopmentExtremitiesGene Expression RegulationI-kappa B ProteinsInflammationMiceMice, Mutant StrainsModels, BiologicalMolecular Sequence DataMorphogenesisNF-kappa BOsteoclastsProtein KinasesSequence AlignmentSequence Homology, Amino AcidSignal TransductionStress, PhysiologicalTranscription, GeneticComparative StudyJournal ArticleReview

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F Mercurio, A M Manning. 1999. Multiple signals converging on NF-kappaB.. https://doi.org/10.1016/s0955-0674(99)80030-1

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