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PubMed · 10209735

Mycobacterium tuberculosis phagosome.

V Deretic·R A Fratti
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Abstract

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.

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Carrier ProteinsCation Transport ProteinsCells, CulturedCytokinesGTP-Binding ProteinsMembrane ProteinsMicroscopy, ConfocalModels, BiologicalMycobacterium bovisMycobacterium tuberculosisPhagocytosisPhagosomesrab GTP-Binding Proteinsrab5 GTP-Binding Proteinsrab7 GTP-Binding ProteinsNatural Resistance-associated Macrophage Protein 1Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

V Deretic, R A Fratti. 1999. Mycobacterium tuberculosis phagosome.. https://doi.org/10.1046/j.1365-2958.1999.01279.x

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