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PubMed · 10222410

A novel method for automatic functional annotation of proteins.

W Fleischmann·S Möller·A Gateau·R Apweiler
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Abstract

MOTIVATION: To cope with the increasing amount of sequence data, reliable automatic annotation tools are required. The TrEMBL database contains together with SWISS-PROT nearly all publicly available protein sequences, but in contrast to SWISS-PROT only limited functional annotation. To improve this situation, we had to develop a method of automatic annotation that produces highly reliable functional prediction using the language and the syntax of SWISS-PROT. RESULTS: An algorithm was developed and successfully used for the automatic annotation of a testset of unknown proteins. The predicted information included description, function, catalytic activity, cofactors, pathway, subcellular location, quaternary structure, similarity to other protein, active sites, and keywords. The algorithm showed a low coverage (10%), but a high specificity and reliability. AVAILABILITY: The results can be obtained by anonymous ftp from ftp.ebi.ac.uk/pub/databases/sp_tr_nrdb. The source code is available on request from the authors.

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AlgorithmsDatabases, FactualProteinsReproducibility of ResultsSoftwareJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

W Fleischmann, S Möller, A Gateau, R Apweiler. 1999. A novel method for automatic functional annotation of proteins.. https://doi.org/10.1093/bioinformatics%2F15.3.228

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