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PubMed · 10229639

Freeze-drying above room temperature.

M S Tesconi·K Sepassi·S H Yalkowsky
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Abstract

This study investigates the use of solid, organic compounds to lyophilize drugs without conventional freeze-drying equipment. The aim of the investigation is to find a pharmaceutically acceptable solvent or solvent combination that is appropriate for freeze-drying on the basis of its ability to (1) solubilize hydrophobic drugs, (2) provide a stable environment for water-sensitive compounds, (3) be rapidly and completely removed from the product under vacuum, and (4) produce cakes that are readily reconstituted. A eutectic formed from 1,1,1-trichloro-2-methyl-2-propanol (chlorobutanol) hemihydrate and dimethyl sulfone (DMSO2) is determined to be a suitable medium.

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BibTeXRIS

M S Tesconi, K Sepassi, S H Yalkowsky. 1999. Freeze-drying above room temperature.. https://doi.org/10.1021/js980478p

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