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PubMed · 102302

Immunoperoxidase study in alpha-chain disease.

P Haghighi·Z Tabei·A Kharazmi·S Gerami·P Abadi·M Haghshenass
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Abstract

Peroxidase-antiperoxidase technique was applied to search for the presence of alpha-chain protein in cells of the infiltrate from six cases of alpha-chain disease (one immunoblastic sarcoma and five plasmacytosis cases). Cases of poorly differentiated lymphocytic and Burkitt's type lymphomas, IgA myeloma, and tuberculous enteritis served as controls. Infiltrate cells from alpha-chain disease showed heavy and diffuse staining with anti-alpha-chain and not light-chain antisera. The myeloma reacted with both anti-alpha and anti-kappa antisera. Plasma cells from tuberculous enteritis showed variable staining with anti-heavy- and anti-light-chain antisera, while control lymphomas did not stain at all. We suggest that immunoenzyme histochemistry is a useful tool in demonstrating intracellular alpha-chain protein.

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Antibodies, Anti-IdiotypicDiagnosis, DifferentialFemaleHeavy Chain DiseaseHumansImmunoenzyme TechniquesImmunoglobulin AImmunoglobulin Heavy ChainsImmunoglobulin alpha-ChainsMaleJournal Article

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P Haghighi, Z Tabei, A Kharazmi, S Gerami, P Abadi, M Haghshenass. 1978. Immunoperoxidase study in alpha-chain disease.. https://pubmed.ncbi.nlm.nih.gov/102302/

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