A three-state model for connexin37 gating kinetics.

S V Ramanan; P R Brink; K Varadaraj; E Peterson; K Schirrmacher; K Banach

doi:10.1016/s0006-3495(99)77406-0

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PubMed · 10233068

A three-state model for connexin37 gating kinetics.

S V Ramanan·P R Brink·K Varadaraj·E Peterson·K Schirrmacher·K Banach

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Abstract

The gating behavior of human connexin 37 (hCx37) is unaffected by the nature of the bathing monovalent (for Na, K, Rb). It is modified by [Mg] in the millimolar range. For fitting the kinetics, we propose a simple extension to three states of the canonical 2-state model of the hemichannel. The extra closed state allows for some immobilization of a hemichannel at high transjunctional voltages. The model is reasonably efficient at fitting data at various voltage protocols. Interpreting the fits of the data at different [Mg] is consistent with a binding site for Mg.

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Biophysical Phenomena Biophysics Connexins Electrochemistry Humans In Vitro Techniques Ion Channel Gating Kinetics Magnesium Models, Biological Recombinant Proteins Transfection Tumor Cells, Cultured Gap Junction alpha-4 Protein Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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S V Ramanan, P R Brink, K Varadaraj, E Peterson, K Schirrmacher, K Banach. 1999. A three-state model for connexin37 gating kinetics.. https://doi.org/10.1016/s0006-3495(99)77406-0

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