PubMed · 10249694
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1980. Coping with fire and arson.. https://pubmed.ncbi.nlm.nih.gov/10249694/
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Intermittent explosive disorder (IED) may best be thought of as a categoric expression of recurrent, problematic impulsive aggressive behavior. Although diagnostic criteria issues have made systematic research in IED difficult, recent work with new research criteria may allow for important empiric work to take place. Given that previous research in the area of impulsive aggression has been highly informative concerning the genetics, biology, and pharmacologic treatment of this behavior, application and extension of this work to IED is crucial. This paper reviews several important aspects of IED including its history in the Diagnostic and Statistical Manual of Mental Disorders, the formation of new research criteria, and the phenomenologic, epidemiologic, genetic, biologic, and treatment correlates of this disorder.
Disorders characterized by impulsivity include disorders of impulse control (intermittent explosive disorder, pyromania, kleptomania, pathological gambling and trichotillomania), paraphilias, sexual impulsions and sexual addictions and impulsive aggression personality disorders (borderline, antisocial, histrionic and narcissistic personality disorders). Impulsivity has a substantial impact on both individuals and society. Impulse control disorders may be conceptualized as a subset of the obsessive-compulsive spectrum. In this article, we examine the genetic and neurobiological aetiology of these disorders and possible treatment options. The link between serotonergic dysfunction and the pathophysiology of impulsivity is discussed, and studies that examine the efficacy of various selective serotonin reuptake inhibitors and other alternatives in the treatment of impulsive disorders such as pathological gambling, sexual addictions and borderline personality disorder are presented.