PubMed Health⌕ Search

PubMed · 10274733

NIH Center grants--PHS. Final rule.

Abstract

These final regulations govern the provision of financial assistance to National Research and Demonstration Centers for Heart, Blood Vessel, Lung and Blood Disease and Blood Resources, Multipurpose Arthritis Centers and Diabetes Research and Training Centers.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

1985-12-04. NIH Center grants--PHS. Final rule.. https://pubmed.ncbi.nlm.nih.gov/10274733/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Interleukin-18 genetics and inflammatory disease susceptibility.

IL18 was mapped to 11q22.2-22.3 in 1998. Owing to interleukin (IL)-18's important and novel role in immunomodulation, the gene itself has been subject to scrutiny, with the aim of discovering variants that may impact on disease susceptibility and/or progression. Despite being sequenced numerous times in different populations, no non-synonymous variants have been found. However, a number of polymorphisms within the proximal promoter have been verified that may interfere with transcription-factor-binding sites. Much of the subsequent association analyses have centred on these variants, but have yielded no consistent results, despite numerous different study populations being genotyped. IL18 has recently been resequenced in its entirety, enabling the tagging-single-nucleotide polymorphism (tSNP) methodology to be adopted. This approach has yielded interesting results, with genetic variation being shown to affect protein levels, and risk. This review aims to compile and reflect on the association data of interest published to date, with a focus on the diseases related to aberrant inflammatory control.

Arthritis↗