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The mouse major histocompatibility complex: some assembly required.

C Amadou·A Kumánovics·E P Jones·D Lambracht-Washington·M Yoshino·K F Lindahl
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Abstract

We have assembled a contig of 81 yeast artificial chromosome clones that spans 8 Mb and contains the entire major histocompatibility complex (Mhc) from mouse strain C57BL/6 (H2b), and we are in the process of assembling an Mhc contig of bacterial artificial chromosome (BAC) clones from strain 129 (H2bc), which differs from C57BL/6 in the H2-Q and H2-T regions. The current BAC contig extends from Tapasin to D17Leh89 with gaps in the class II, H2-Q, and distal H2-M regions. Only four BAC clones were required to link the class I genes of the H2-Q and H2-T regions, and no new class I gene was found in the previous gap. The proximal 1 Mb of the H2-M region has been analyzed in detail and is ready for sequencing; it includes 21 class I genes or fragments, at least 14 olfactory receptor-like genes, and a number of non-class I genes that clearly establish a conserved synteny with the class I regions of the human and rat Mhc.

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AnimalsContig MappingH-2 AntigensHumansMajor Histocompatibility ComplexMiceMice, Inbred C57BLJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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C Amadou, A Kumánovics, E P Jones, D Lambracht-Washington, M Yoshino, K F Lindahl. 1999. The mouse major histocompatibility complex: some assembly required.. https://doi.org/10.1111/j.1600-065x.1999.tb01394.x

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