Nitric oxide and cell death.

M P Murphy

doi:10.1016/s0005-2728(99)00029-8

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Nitric oxide and cell death.

M P Murphy

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Abstract

Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production can cause cell death through oxidative stress, disrupted energy metabolism, DNA damage, activation of poly(ADP-ribose) polymerase, or dysregulation of cytosolic calcium. Such disturbances can lead to either apoptotic or necrotic cell death, depending on the severity and context of the damage. Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.

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Animals Apoptosis DNA Damage Energy Metabolism Humans Mitochondria Neurodegenerative Diseases Nitric Oxide Oxidative Stress Journal Article Research Support, Non-U.S. Gov't Review

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M P Murphy. 1999-05-05. Nitric oxide and cell death.. https://doi.org/10.1016/s0005-2728(99)00029-8

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