Nitric oxide in septic shock.

M A Titheradge

doi:10.1016/s0005-2728(99)00031-6

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PubMed · 10320674

Nitric oxide in septic shock.

M A Titheradge

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Abstract

Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by hypotension and vascular collapse, with a failure of the major organs within the body. The role of excessive nitric oxide (NO) production, following the cytokine-dependent induction of the inducible nitric oxide synthase (iNOS), in the development of septic shock is discussed. Emphasis is placed upon the signal-transduction process by which iNOS is induced and the role of NO in cellular energy dysfunction and the abnormal function of the cardiovascular system and liver during septic shock.

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Animals Apoptosis Endothelium, Vascular Enzyme Induction Humans Lipopolysaccharides Liver Models, Chemical Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type II Shock, Septic Signal Transduction Journal Article Review

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M A Titheradge. 1999-05-05. Nitric oxide in septic shock.. https://doi.org/10.1016/s0005-2728(99)00031-6

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