Hypermutation in antibody affinity maturation.

M Wabl; M Cascalho; C Steinberg

doi:10.1016/s0952-7915(99)80031-4

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Hypermutation in antibody affinity maturation.

M Wabl·M Cascalho·C Steinberg

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Abstract

By studying the role of mismatch repair in hypermutation at the immunoglobulin loci, the field of antibody hypermutation has been integrated into the larger area of DNA repair. Trans-acting factors - Ku70, Ku80 and possibly SWAP-70 - have been identified for the temporally related but not mechanistically related immunoglobulin heavy-chain class-switch.

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Animals Antibody Affinity DNA Repair Genes, Immunoglobulin Humans Immunoglobulin Class Switching Immunoglobulin Heavy Chains Mutation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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M Wabl, M Cascalho, C Steinberg. 1999. Hypermutation in antibody affinity maturation.. https://doi.org/10.1016/s0952-7915(99)80031-4

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