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PubMed · 10322154

Helper T cell differentiation.

S L Swain
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Abstract

The differentiation of Th cells is regulated at different points by antigen and by other factors in a complex fashion that allows impressive flexibility in the T cell response generated and enables close control at multiple points to prevent an unwanted response. Studies over the past two years have uncovered several principles of this regulation, including a new appreciation of the critical role of survival factors in determining the success of the immune response. New insights into the details of CD4(+) T cell regulation will provide important clues as to how immune responses are regulated, in particular the generation of effector responses and development of long-lived immunity.

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AnimalsApoptosisCell DifferentiationCytokinesHumansImmunologic MemoryLymphocyte ActivationT-Lymphocytes, Helper-InducerJournal ArticleReview

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BibTeXRIS

S L Swain. 1999. Helper T cell differentiation.. https://doi.org/10.1016/s0952-7915(99)80030-2

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