Structure and function of the Arp2/3 complex.

R D Mullins; T D Pollard

doi:10.1016/s0959-440x(99)80034-7

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Structure and function of the Arp2/3 complex.

R D Mullins·T D Pollard

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Abstract

The Arp2/3 complex is a ubiquitous and essential component of the actin cytoskeleton in eukaryotic cells. It nucleates actin filaments, caps their pointed ends and cross-links them into orthogonal networks. In amoeba, vertebrates and fungi, the complex consists of actin-related proteins Arp2 and Arp3 and individual copies of five novel polypeptides. The Arps are thought to mediate pointed-end capping and nucleation. Chemical cross-linking implicates three subunits in binding the complex to the side of another actin filament.

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R D Mullins, T D Pollard. 1999. Structure and function of the Arp2/3 complex.. https://doi.org/10.1016/s0959-440x(99)80034-7

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