Growing up on the streets: why B-cell development differs from T-cell development.

S E Townsend; B C Weintraub; C C Goodnow

doi:10.1016/s0167-5699(98)01440-6

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Growing up on the streets: why B-cell development differs from T-cell development.

S E Townsend·B C Weintraub·C C Goodnow

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Abstract

B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.

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Animals Antigens Autoimmunity B-Lymphocytes Cell Differentiation Humans Spleen T-Lymphocytes Journal Article Review

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S E Townsend, B C Weintraub, C C Goodnow. 1999. Growing up on the streets: why B-cell development differs from T-cell development.. https://doi.org/10.1016/s0167-5699(98)01440-6

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