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PubMed · 10322304

How LFA-1 binds to different ligands.

M E Binnerts·Y van Kooyk
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Abstract

The integrin leukocyte function-associated antigen 1 (LFA-1) is pivotal for cell adhesion and signalling within the immune system. Here, Minke Binnerts and Yvette van Kooyk discuss evidence from mutational and crystallographic studies showing that binding of LFA-1 to its ligands intercellular adhesion molecule 1 (ICAM-1), -2 and -3 might be structurally distinct.

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AnimalsBinding SitesCell Adhesion MoleculesHumansLigandsLymphocyte Function-Associated Antigen-1Models, MolecularProtein ConformationJournal ArticleResearch Support, Non-U.S. Gov't

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M E Binnerts, Y van Kooyk. 1999. How LFA-1 binds to different ligands.. https://doi.org/10.1016/s0167-5699(99)01467-x

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