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PubMed · 10322433

The WD repeat: a common architecture for diverse functions.

T F Smith·C Gaitatzes·K Saxena·E J Neer
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Abstract

Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions. The solution of the three-dimensional structure of one WD-repeat protein and the assumption that the structure will be common to all members of this family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable surface similarity. Proteins that have very similar surfaces are likely to have common binding partners and similar functions.

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AnimalsArabidopsisCaenorhabditis elegansFungal ProteinsGTP-Binding ProteinsProtein ConformationProteinsRepetitive Sequences, Amino AcidJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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T F Smith, C Gaitatzes, K Saxena, E J Neer. 1999. The WD repeat: a common architecture for diverse functions.. https://doi.org/10.1016/s0968-0004(99)01384-5

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