c-Myb is essential for early T cell development.

R D Allen; T P Bender; G Siu

doi:10.1101/gad.13.9.1073

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c-Myb is essential for early T cell development.

R D Allen·T P Bender·G Siu

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Abstract

The c-Myb transcription factor is important for fetal hematopoiesis and has been proposed to mediate later stages of lymphocyte development. Using homozygous null c-Myb/Rag1 chimeric mice, we have determined that c-Myb plays an important role in the differentiation of macrophages and lymphocytes from precursor stem cells. We also determine that deletion of c-Myb leads to a complete block in early T cell development just before the oligopotent thymocyte matures into the definitive T cell precursor. These data indicate that c-Myb plays an important role at multiple stages of hematopoiesis and is required at an early stage of T cell development.

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Animals Cell Differentiation Genes, RAG-1 Hematopoiesis Hematopoietic Stem Cells Hyaluronan Receptors Macrophages Mice Mice, Knockout Oncogenes Receptors, Interleukin-2 T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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R D Allen, T P Bender, G Siu. 1999-05-01. c-Myb is essential for early T cell development.. https://doi.org/10.1101/gad.13.9.1073

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