Glucotoxicity: potential mechanisms.

A D Mooradian; J E Thurman

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PubMed · 10339632

Glucotoxicity: potential mechanisms.

A D Mooradian·J E Thurman

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Abstract

Plasma concentration of glucose is found within a relatively narrow range of values for most animal species, yet it has little correlation with maximum lifespan; however, hyperglycemia in most animals is associated with premature death. This article presents evidence for hyperglycemia-induced tissue toxicity and discusses potential mechanisms of glucotoxicity and implications for the aging organism.

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Age Factors Aged Animals Diabetes Complications Female Glucose Humans Hyperglycemia Male Oxidative Stress Risk Assessment Journal Article Review

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A D Mooradian, J E Thurman. 1999. Glucotoxicity: potential mechanisms.. https://pubmed.ncbi.nlm.nih.gov/10339632/

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