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Decrease in spontaneous motor activity and in brain lipid peroxidation in manganese and melatonin treated mice.

E J Talavera·J L Arcaya·D Giraldoth·J Suárez·E Bonilla
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Abstract

In the present study, we have evaluated whether melatonin (MEL) modulates Mn-induced decrease in spontaneous motor activity (SMA) and lipid peroxidation, estimated as malondialdehyde (MDA) formation, in several brain regions. In mice treated with manganese a decrease in SMA after 2 weeks of treatment was observed. In the group treated with Mn+MEL a significant greater reduction in SMA was detected at 4 weeks. MDA levels were reduced in both MEL and Mn treated mice. In the animals treated with MEL + Mn a higher reduction in MDA levels was observed. These results suggest that MEL modulates the effect of Mn on SMA and brain lipid peroxidation.

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AnimalsBrainDrug InteractionsKineticsLipid PeroxidationMalondialdehydeManganeseMelatoninMiceMotor ActivityJournal ArticleResearch Support, Non-U.S. Gov't

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E J Talavera, J L Arcaya, D Giraldoth, J Suárez, E Bonilla. 1999. Decrease in spontaneous motor activity and in brain lipid peroxidation in manganese and melatonin treated mice.. https://doi.org/10.1023/a%3A1021064711866

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