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PubMed · 10359715

Solution-phase chemical library synthesis using polymer-assisted purification techniques.

J J Parlow·R V Devraj·M S South
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Abstract

During the past few years, polymer-assisted solution-phase synthesis has become a prevalent method for the parallel synthesis of chemical libraries. This methodology allows for intermediate and final product purification by various resin-based sequestration techniques, which allow for the removal of excess reactants, by-products or side products from solution-phase reactions. The methodology has continued to expand, providing the practitioner with a broad range of ingenious purification methods, allowing single-step transformations as well as multistep syntheses to be performed in solution. The polymer-assisted solution-phase technology is currently being utilized for both the synthesis of lead generation and lead optimization libraries in the pharmaceutical arena and has also expanded into other disciplines.

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BibTeXRIS

J J Parlow, R V Devraj, M S South. 1999. Solution-phase chemical library synthesis using polymer-assisted purification techniques.. https://doi.org/10.1016/s1367-5931(99)80049-0

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