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Does maximizing programmed cell death necessarily yield an optimum clinical advantage?

D Ou·K M Anderson·W Leslie·P Bonomi·J E Harris
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Abstract

Generally it has been believed that a maximum therapeutic induction of programmed cell death in cancer cells is universally desirable. As a corollary, the presence of Bcl-2, a major anti-programmed cell death protein, is considered an unfavorable prognostic sign. The latter is not and the former may not be universally true.

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AnimalsApoptosisHumansModels, BiologicalNeoplasmsPrognosisProto-Oncogene Proteins c-bcl-2Journal ArticleResearch Support, Non-U.S. Gov't

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D Ou, K M Anderson, W Leslie, P Bonomi, J E Harris. 1999. Does maximizing programmed cell death necessarily yield an optimum clinical advantage?. https://doi.org/10.1054/mehy.1998.0839

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