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PubMed · 10367540

[Gemcitabine in advanced stage soft tissue sarcoma: a phase II study].

A Amodio·S Carpano·C Manfredi·G Del Monte·L Di Lauro·T Gionfra·F Conti·G Paoletti·M Lopez
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Abstract

PURPOSE: To assess the activity and toxicity of gemcitabine in locally advanced or metastatic soft tissue sarcoma patients (pts). PATIENTS AND METHODS: Gemcitabine was administered on days 1, 8, 15 every 4 weeks at a dose of 1.000/1.250 mg/m2, respectively, in pretreated or not pretreated pts. RESULTS: Eighteen pts entered this phase II trial; sixteen had been previously treated with anthracyclines and ifosfamide. A partial response was observed in a woman with fibrous malignant istocytoma, whereas in 7 pts the disease remained stable. Median time to progression was 4 months. The treatment was well tolerated. Grade 4 toxicity was not observed. CONCLUSIONS: These results do not suggest that gemcitabine, in the dose and schedule used in this trial, may be of value in the treatment of soft tissue sarcomas.

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Antimetabolites, AntineoplasticDeoxycytidineFemaleHumansNeoplasm StagingSarcomaGemcitabineClinical TrialClinical Trial, Phase IIEnglish AbstractJournal ArticleRandomized Controlled TrialReview

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A Amodio, S Carpano, C Manfredi, G Del Monte, L Di Lauro, T Gionfra, F Conti, G Paoletti, M Lopez. [Gemcitabine in advanced stage soft tissue sarcoma: a phase II study].. https://pubmed.ncbi.nlm.nih.gov/10367540/

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