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Polymorphism of disopyramide.

S R Gunning·M Freeman·J A Stead
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Abstract

Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144 kJ mol-1 is calculated for the system. Dissolution and plasma concentrations show no significant differences in bioavailability between the two polymorphs.

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Biological AvailabilityBiotransformationChemical PhenomenaChemistry, PhysicalDisopyramideFemaleHumansHydrogen-Ion ConcentrationIsomerismKineticsMalePyridinesSolubilityX-Ray DiffractionJournal Article

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S R Gunning, M Freeman, J A Stead. 1976. Polymorphism of disopyramide.. https://doi.org/10.1111/j.2042-7158.1976.tb04042.x

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