PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 10380277

Future research in meniscal replacement.

K Messner·D Kohn·R Verdonk
View original source ↗Export metadata ↓

Abstract

To study the remodelling process after meniscus replacement and to learn how to control it will be a key topic for future research. Not enough is known about the importance of precision in meniscal fixation and how to make the insertions as strong as in the normal meniscus. Methods to measure load-distribution, mechanical properties of the graft and status of the cartilage should be developed. A number of different auto- and allografts have been shown to heal and revascularize, but whether the grafts are functioning is not known. Meniscal scaffolds, which can be used for replacement of partial meniscal loss, need to be tested. Scaffolds and tissue engineering will be the subject of intensive research in the future.

Explore related subjects

CryopreservationHumansMenisci, TibialRegenerationResearchTransplantation, AutologousTransplantation, HomologousJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

K Messner, D Kohn, R Verdonk. 1999. Future research in meniscal replacement.. https://doi.org/10.1111/j.1600-0838.1999.tb00451.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2026

Isolation and Cultivation of Diplonemids.

Marine diplonemids (Diplonemidae and Hemistasiidae), once considered difficult to culture, can now be introduced into stable axenic cultures and grown to high densities. This chapter provides detailed protocols on establishing clonal cultures from environmental cells, their axenization and routine maintenance, as well as instructions on mid- and large-scale cultivation, estimation of cell density, and cryopreservation of selected species.

Cryopreservation↗
PubMed2006

Laparoscopic ovariectomy for whole human ovary cryopreservation: technical aspects.

OBJECTIVE: To describe the technique of laparoscopic ovariectomy with a view to cryopreservation of a whole ovary with its vascular pedicle. DESIGN: Descriptive study. SETTING: Gynecology research unit in a department of gynecology in a university hospital. PATIENT(S): Women with indications for chemotherapy or radiotherapy who are at high risk of premature ovarian failure. INTERVENTION(S): Laparoscopic ovariectomy for whole ovary cryopreservation in nine patients. MAIN OUTCOME MEASURE(S): Feasibility of laparoscopic ovariectomy for whole ovary cryopreservation and later autotransplantation without delaying chemotherapy. RESULT(S): The whole ovary was successfully removed by laparoscopy and cryopreserved by arterial catheterization in all nine patients. CONCLUSION(S): Ovariectomy with a view to whole ovary cryopreservation for future transplantation may be performed by laparoscopy. Great care must be taken to remove the ovary, together with a large part (> or =5 cm) of the infundibulopelvic ligament, allowing dissection of the ovarian vessels, perfusion with a cryoprotective medium, and cryopreservation for subsequent autografting of the whole ovary. The period of ischemia between ligation of the ovarian pedicle and ovarian cryopreservation must be as short as possible.

Cryopreservation↗