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PubMed · 10389552

Desensitization to 5-fluorouracil.

T Eppinger·K Sperber
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Abstract

Anaphylactic reactions to 5-fluorouracil (5-FU) are uncommon. We report a 40-year-old female with adenocarcinoma of the ovary who had two reactions immediately after being infused with 5-FU. The second reaction occurred despite prophylaxis with steroids and antihistamines. The patient was positive to 5-FU on puncture skin testing even though there was no previous exposure to the drug. We successfully desensitized her to 5-FU using a continuous intravenous protocol with sequential increments in the fusion rates and drug concentrations. This desensitization method may be useful to manage systemic reactions to 5-FU and other drugs.

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AdenocarcinomaAdultAnaphylaxisAntimetabolites, AntineoplasticDesensitization, ImmunologicFemaleFluorouracilHumansImmunoglobulin EInfusions, IntravenousOvarian NeoplasmsSkin TestsCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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T Eppinger, K Sperber. Desensitization to 5-fluorouracil.. https://doi.org/10.2500/108854199778553064

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