CD14.

C Schütt

doi:10.1016/s1357-2725(98)00153-8

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PubMed · 10399315

CD14.

C Schütt

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Abstract

The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not have a membrane spanning domain it cannot transmit a signal into the cell. Some as yet unidentified accessory protein is thought to be involved. It will be important to clarify the signalling systems involved since they may provide a therapeutic target for sepsis intervention strategies.

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Animals Humans Lipopolysaccharide Receptors Lipopolysaccharides Macrophages Mice Mice, Knockout Models, Biological Receptors, Immunologic Sepsis Journal Article Review

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C Schütt. 1999. CD14.. https://doi.org/10.1016/s1357-2725(98)00153-8

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