A protein taxonomy based on secondary structure.

T Przytycka; R Aurora; G D Rose

doi:10.1038/10728

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A protein taxonomy based on secondary structure.

T Przytycka·R Aurora·G D Rose

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Abstract

Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves. Our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.

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Algorithms Animals Classification Computer Simulation Databases, Factual Evolution, Molecular Protein Folding Protein Structure, Secondary Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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T Przytycka, R Aurora, G D Rose. 1999. A protein taxonomy based on secondary structure.. https://doi.org/10.1038/10728

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