Biomimicry 1: PC.

D C Cumberland; J Gunn; N Malik; C M Holt

PubMed · 10406685

Biomimicry 1: PC.

Abstract

The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.

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Animals Coated Materials, Biocompatible Coronary Vessels Humans Phosphorylcholine Polymers Prosthesis Design Stents Journal Article Review

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D C Cumberland, J Gunn, N Malik, C M Holt. Biomimicry 1: PC.. https://pubmed.ncbi.nlm.nih.gov/10406685/

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