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Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function.

P C White·A Hautanen·M Kupari
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Abstract

In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.

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AllelesBaroreflexCardiomegalyCardiovascular Physiological PhenomenaCytochrome P-450 CYP11B2HumansOrgan SizePolymorphism, GeneticJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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P C White, A Hautanen, M Kupari. Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function.. https://doi.org/10.1016/s0960-0760(99)00071-0

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