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Solid-phase total synthesis of polymyxin B1.

S K Sharma·A D Wu·N Chandramouli·C Fotsch·G Kardash·K W Bair
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Abstract

The total solid-phase synthesis of polymyxin B1 (PMB1) has been achieved in 20% yield using the orthogonal protecting group N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-(Dde). This report demonstrates that a complex peptide macrocycle can be synthesized in high yields using solid-phase synthesis. According to MS and HPLC, the synthetic peptide was identical to the naturally occurring antibiotic.

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Chromatography, High Pressure LiquidMass SpectrometryModels, MolecularPolymyxin BPolymyxinsJournal Article

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S K Sharma, A D Wu, N Chandramouli, C Fotsch, G Kardash, K W Bair. 1999. Solid-phase total synthesis of polymyxin B1.. https://doi.org/10.1034/j.1399-3011.1999.00045.x

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