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PubMed · 10431472

[Atypical antipsychotics].

C Massoubre·F Lang
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Abstract

This paper synthetizes important information concerning principal atypical antipsychotic drugs actually used in clinical practice: classification, pharmacokinetics, therapeutic uses, side effects, contra-indications and drug interactions. These molecules have heterogeneous structures, but are more and more used because of good neurological tolerance, greater efficacy against negative symptoms, and for clozapin greater efficacy against resistant schizophrenia.

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C Massoubre, F Lang. [Atypical antipsychotics].. https://pubmed.ncbi.nlm.nih.gov/10431472/

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PubMed2007

Differential pharmacology of atypical antipsychotics: clinical implications.

PURPOSE: Pharmacology of atypical antipsychotics and the clinical implications are reviewed. SUMMARY: Psychiatric disorders, such as schizophrenia and bipolar disorder, are often associated with poor outcomes. Atypical antipsychotics have become the standard of care for these disorders, and multiple agents have demonstrated efficacy for both acute and maintenance therapy. As a result of their differential pharmacologic properties, atypical antipsychotics have diverse clinical profiles, resulting in different liabilities for specific adverse events. These effects can, in turn, have an adverse impact on patient functionality, adherence to therapy, and overall health. CONCLUSION: Atypical antipsychotics have distinct pharmacological profiles which result in clinically meaningful differences in adverse effects. Clinicians should have a wide choice of agents available with which to optimize outcomes in the majority of patients with psychiatric disorders.

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