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PubMed · 10433657

Central nervous system infections. Basic concepts.

D S King
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Abstract

Central nervous system infections have the potential to be very dangerous and life-threatening. Advances in the understanding and care of patients experiencing these infections have aided in their detection and treatment. Caring for these patients requires a thorough knowledge of the diseases as well as a holistic approach which encompasses the patient and family.

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Central Nervous System InfectionsHumansIncidenceNeurologic ExaminationNursing AssessmentRisk FactorsJournal ArticleReview

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D S King. 1999. Central nervous system infections. Basic concepts.. https://pubmed.ncbi.nlm.nih.gov/10433657/

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Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system.

Enterovirus 71 (EV71) infection can lead to devastating clinical outcomes. An appreciation of the scientific relationship between cytokine response and patient mortality may help limit the risks posed by this deadly illness. We present the results of a study that compared the cerebrospinal fluid (CSF) and serum levels of interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in 24 patients with EV71 infection. Cases in this study involved diverse manifestations or complications, including encephalitis, poliomyelitis-like syndrome, meningitis, and pulmonary edema. CSF levels of IL-6 in study patients were found to be consistently higher during the first 2 days of central nervous system (CNS) involvement than afterward. Compared with patients who did not have pulmonary edema, patients who experienced pulmonary edema had dramatically varied blood values, including IL-6, white blood cell counts, and glucose levels. Our findings suggest that the combination of CNS and systemic inflammatory response may trigger EV71-related cardiopulmonary collapse.

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