Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.

C S Jensen; A Kong

doi:10.1086/302524

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Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.

C S Jensen·A Kong

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Abstract

We apply the method of "blocking Gibbs" sampling to a problem of great importance and complexity-linkage analysis. Blocking Gibbs sampling combines exact local computations with Gibbs sampling, in a way that complements the strengths of both. The method is able to handle problems with very high complexity, such as linkage analysis in large pedigrees with many loops, a task that no other known method is able to handle. New developments of the method are outlined, and it is applied to a highly complex linkage problem in a human pedigree.

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Algorithms Alleles Bayes Theorem Female Genetic Linkage Genotype Humans Likelihood Functions Lod Score Long QT Syndrome Male Pedigree Phenotype Recombination, Genetic Comparative Study Journal Article

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C S Jensen, A Kong. 1999. Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.. https://doi.org/10.1086/302524

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