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PubMed · 10442450

Type-2 diabetes and cognitive function in a non-demented population.

M Vanhanen·J Kuusisto·K Koivisto·L Mykkänen·E L Helkala·T Hänninen·P Riekkinen·H Soininen·M Laakso
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Abstract

OBJECTIVES: To study if type-2 (non-insulin-dependent) diabetes mellitus (NIDDM) is associated with cognitive dysfunction independently of clinically diagnosed dementia in an elderly population. MATERIAL AND METHODS: Cognitive function was investigated with a brief neuropsychological test battery in a non-demented elderly population consisting of 183 NIDDM (World Health Organization, 1985) patients and 732 non-diabetic subjects. RESULTS: Patients with NIDDM were impaired in the Trail-Making Test parts A and C, which may be a reflection of mildly affected frontal lobe/executive functions. Women with NIDDM performed better than non-diabetic subjects in the Mini-Mental State Examination. CONCLUSIONS: We conclude that NIDDM per se is not associated with impaired memory in the elderly, and the minor defects observed in tests of frontal lobe/executive functions are unlikely to affect daily living. In the non-demented population aged 69 78 years, NIDDM does not carry a significant risk of cognitive dysfunction, when compared to the non-diabetic subjects.

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Activities of Daily LivingAgedBrain Damage, ChronicCognition DisordersDementiaDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleHumansIntracranial ArteriosclerosisMaleMental Status ScheduleNeuropsychological TestsRisk FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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M Vanhanen, J Kuusisto, K Koivisto, L Mykkänen, E L Helkala, T Hänninen, P Riekkinen, H Soininen, M Laakso. 1999. Type-2 diabetes and cognitive function in a non-demented population.. https://doi.org/10.1111/j.1600-0404.1999.tb01045.x

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