Basic mechanisms of monogenic inheritance.

A Ziegler

doi:10.1111/j.1528-1157.1999.tb00891.x

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Basic mechanisms of monogenic inheritance.

A Ziegler

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Abstract

To revive the appreciation of the importance of genetic studies for the understanding of neurologic diseases inherited in a monogenic fashion. After a description of the basic patterns of monogenic inheritance, the importance of linkage studies for the mapping of a disease gene is mentioned. Furthermore, the term linkage disequilibrium is introduced. Finally, several procedures used in current linkage analyses are briefly mentioned, with the aim of identifying the disease gene. The importance of genetic studies of disease families with many members, preferably from isolated surroundings to favor homogeneity, is stressed. However, such analyses can be performed only as a consequence of a close cooperation between clinicians and research scientists.

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Animals Chromosome Mapping Epilepsy Family Female Genetic Markers Genetics, Medical Genotype Humans Linkage Disequilibrium Lod Score Male Models, Genetic Music Mutation Phenotype Journal Article Research Support, Non-U.S. Gov't

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A Ziegler. 1999. Basic mechanisms of monogenic inheritance.. https://doi.org/10.1111/j.1528-1157.1999.tb00891.x

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