Myocardial preconditioning: basic concepts and potential mechanisms.

S Okubo; L Xi; N L Bernardo; K Yoshida; R C Kukreja

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PubMed · 10448897

Myocardial preconditioning: basic concepts and potential mechanisms.

S Okubo·L Xi·N L Bernardo·K Yoshida·R C Kukreja

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Abstract

Preconditioning is a phenomenon, where brief periods of stress such as ischemia, heat shock or certain pharmacological agents make the heart tolerant to subsequent lethal ischemic injury. Preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel and expression of a number of protective proteins. In this review, the potential role of these mechanisms is discussed.

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Animals Humans Ischemic Preconditioning, Myocardial Models, Cardiovascular Journal Article Review

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S Okubo, L Xi, N L Bernardo, K Yoshida, R C Kukreja. 1999. Myocardial preconditioning: basic concepts and potential mechanisms.. https://pubmed.ncbi.nlm.nih.gov/10448897/

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