Using pair-coupled amino acid composition to predict protein secondary structure content.

K C Chou

doi:10.1023/a:1020696810938

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Using pair-coupled amino acid composition to predict protein secondary structure content.

K C Chou

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Abstract

The pair-coupled amino acid composition is introduced to predict the secondary structure contents of a protein. Compared with the existing methods all based on singlewise amino acid composition as defined in a 20D (dimensional) space, this represents a step forward to the consideration of the sequence coupling effect. The test results indicate that the introduction of the pair-coupled amino acid composition can significantly improve the prediction quality. It is anticipated that the concept of the pair-coupled amino acid composition can be used to simplify the formulation of sequence coupling (or sequence order) effects and to study many other features of proteins as well.

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Algorithms Amino Acids Hydrogen Bonding Mathematics Protein Conformation Protein Structure, Secondary Journal Article

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K C Chou. 1999. Using pair-coupled amino acid composition to predict protein secondary structure content.. https://doi.org/10.1023/a%3A1020696810938

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