Structure and function of the P-type ATPases.

G A Scarborough

doi:10.1016/s0955-0674(99)80075-1

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Structure and function of the P-type ATPases.

G A Scarborough

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Abstract

The P-type ATPases are integral membrane proteins that generate essential transmembrane ion gradients in virtually all living cells. The structures of two of these have recently been elucidated at a resolution of 8 A. When considered together with the large body of biochemical information that has accrued for these transporters and for enzymes in general, this new structural information is providing tantalizing insights regarding the molecular mechanism of active ion transport catalyzed by these proteins.

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Animals Biological Transport Calcium-Transporting ATPases Cytoplasm Protein Conformation Proton-Translocating ATPases Structure-Activity Relationship Journal Article Research Support, U.S. Gov't, P.H.S.Review

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G A Scarborough. 1999. Structure and function of the P-type ATPases.. https://doi.org/10.1016/s0955-0674(99)80075-1

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