Disease models provide insights into post-golgi protein trafficking, localization and processing.

D Shields; P Arvan

doi:10.1016/s0955-0674(99)80070-2

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Disease models provide insights into post-golgi protein trafficking, localization and processing.

D Shields·P Arvan

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Abstract

Over the past two years, the use of in vitro systems and the identification of autoantibodies to Golgi proteins have provided important new tools for analyzing vesicle and cargo trafficking in the distal secretory pathway. In addition, the phenotypic characterization of mice with knockouts of various prohormone convertases has led to significant progress in understanding the biological relevance of prohormone processing in post-Golgi compartments.

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Animals Biological Transport Cytoplasmic Granules Disease Models, Animal Endopeptidases Golgi Apparatus Humans Mice Oculocerebrorenal Syndrome Protein Processing, Post-Translational Proteins Journal Article Research Support, U.S. Gov't, P.H.S.Review

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D Shields, P Arvan. 1999. Disease models provide insights into post-golgi protein trafficking, localization and processing.. https://doi.org/10.1016/s0955-0674(99)80070-2

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