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PubMed · 10452530

Oligonucleotide-peptide conjugates as potential antisense agents.

E M Zubin·E A Romanova·E M Volkov·V N Tashlitsky·G A Korshunova·Z A Shabarova·T S Oretskaya
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Abstract

Oligonucleotide-peptide conjugates have several applications, including their potential use as improved antisense agents for interfering with the RNA function within cells. In order to provide robust and generally applicable conjugation chemistry, we developed a novel approach of fragment coupling of pre-synthesized peptides to the 2'-position of a selected nucleotide within an otherwise protected oligonucleotide chain attached to a solid support.

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AdenosineArabinonucleosidesBiochemistryChromatography, High Pressure LiquidNucleoproteinsOligonucleotidesOligonucleotides, AntisensePeptidesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationJournal ArticleResearch Support, Non-U.S. Gov't

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E M Zubin, E A Romanova, E M Volkov, V N Tashlitsky, G A Korshunova, Z A Shabarova, T S Oretskaya. 1999-07-30. Oligonucleotide-peptide conjugates as potential antisense agents.. https://doi.org/10.1016/s0014-5793(99)00921-7

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