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Which T cells cause psoriasis?

J C Prinz
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Abstract

Today, T cells appear to be the main protagonists in the pathogenesis of psoriasis vulgaris. This article summarizes how T cells might contribute to the generation of psoriatic skin lesions. It discusses the preferential T cell receptor usage and the putative mode of T cell activation in psoriatic skin lesions, and how streptococcal throat infections could be involved in disease manifestations. The results are integrated into a pathogenetic concept which considers psoriasis as a T-cell mediated autoimmune disorder.

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Autoimmune DiseasesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesGene Rearrangement, T-LymphocyteHumansKeratinocytesLymphocyte ActivationPharyngitisPsoriasisReceptors, Antigen, T-CellStreptococcal InfectionsSuperantigensT-LymphocytesJournal ArticleReview

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BibTeXRIS

J C Prinz. 1999. Which T cells cause psoriasis?. https://doi.org/10.1046/j.1365-2230.1999.00483.x

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