Gamma-tubulin complexes: size does matter.

R Jeng; T Stearns

doi:10.1016/s0962-8924(99)01621-9

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PubMed · 10461186

Gamma-tubulin complexes: size does matter.

R Jeng·T Stearns

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Abstract

gamma-Tubulin is a conserved component of all microtubule-organizing centres and is required for these organelles to nucleate microtubule polymerization. However, the mechanism of nucleation is not known. In addition to its localization to organizing centres, a large pool of gamma-tubulin exists in the cytoplasm in a complex with other proteins. The size of the gamma-tubulin complex and number of associated proteins vary among organisms, and the functional significance of these differences is unknown. Recently, the nature of these gamma-tubulin complexes has been explored in different organisms, and this has led us closer to a molecular understanding of microtubule nucleation.

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Animal Population Groups Animals Centrosome Drosophila melanogaster Fungal Proteins Fungi Insect Proteins Macromolecular Substances Microtubules Morphogenesis Spindle Apparatus Structure-Activity Relationship Tubulin Comparative Study Journal Article Review

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R Jeng, T Stearns. 1999. Gamma-tubulin complexes: size does matter.. https://doi.org/10.1016/s0962-8924(99)01621-9

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