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PubMed · 10471768

Osteoinductive bone graft substitutes for spinal fusion: a basic science summary.

S C Ludwig·S D Boden
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Abstract

An understanding of precise biologic mechanisms at work during spinal fusion healing is just beginning to evolve. Current molecular biology research has shown this process to be multifactorial and extremely complex. With the advent of improved animal models to study the biology of spinal fusion, essential information regarding the basic science behind arthrodesis has advanced knowledge of this process. Moreover, with advances in local gene therapy as well as osteoinductive proteins and osteoinductive carrier matrices, the orthopedic surgeon will soon enter into a new era of biologic manipulation for fusion.

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AnimalsBiologyBone MatrixBone Morphogenetic ProteinsBone SubstitutesBone TransplantationDecalcification TechniqueDisease Models, AnimalGenetic TherapyHumansMolecular BiologyOsteogenesisRecombinant ProteinsSpinal FusionWound HealingJournal ArticleReview

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S C Ludwig, S D Boden. 1999. Osteoinductive bone graft substitutes for spinal fusion: a basic science summary.. https://doi.org/10.1016/s0030-5898(05)70116-4

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